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. 2021 Jun 15;96(24):e2933–e2943. doi: 10.1212/WNL.0000000000012108

Figure 4. Entorhinal FDG Predicts Subsequent Cognitive Decline Independently of PiB and FTP.

Figure 4

Backward stepwise regressions identified the strongest predictors of subsequent cognitive decline in the (A) entire sample, (B) low–Pittsburgh compound B (PiB) subgroup, and (C) high-PiB subgroup. We used a liberal threshold in this test (2-tailed p ≤ 0.10) and removed nonsignificant predictors from the model. (A) PiB frontal, lateral temporal, and retrosplenial cortices (FLR), entorhinal cortex (EC) flortaucipir (FTP), EC fluorodeoxyglucose (FDG), and age were independently predictive of cognitive decline in the entire sample. (B) Age was the only predictor of cognitive decline in the low-PiB group. (C) EC FDG, EC FTP, and hippocampus volume (HV) were independently predictive in the high-PiB group. Although PiB and FTP estimates are negative, they are presented in the positive range to facilitate the comparison with FDG and HV.