Skip to main content
. 2021 Jun 25;2021:5927064. doi: 10.1155/2021/5927064

Figure 1.

Figure 1

TL1A in colon tissue of patients with ulcerative colitis (UC) and Crohn's disease (CD) correlates with fibrosis score and EMT-related markers. Colon tissues from CD patients (n = 10), UC patients (n = 12), and controls (n = 8) were included. (a, b) Representative microscopic images of hematoxylin and eosin- (H&E-) stained paraffin-embedded colonic tissue samples (100x), and the quantitative determination of fibrosis area based on Sirius red staining (100x). (c) Immunofluorescence double staining. E-cadherin (green), α-SMA (red), and colocalization (yellow) in colon tissue samples of IBD patients and controls (400x). DAPI stains nuclei (blue). (d) Immunohistochemical staining of β-catenin, TL1A, E-cadherin, FSP1, and α-SMA in colon tissues of controls and IBD patients (400x), and mean density of nuclear localization of β-catenin and expressions of TL1A, FSP1, and α-SMA were increased in the UC and CD groups; however, the mean density of E-cadherin was decreased in the UC and CD groups. (e) Pearson's correlation and linear analysis. Data were given as mean ± standard deviation (SD). As compared to the control group: ∗P < 0.05, ∗∗P ≤ 0.01, and ∗∗∗P ≤ 0.001.