Table 2.
Outcomes.
| Coronavirus |
Influenza (n = 429) |
p-value |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Total* (n = 495) |
AC** (n = 65) |
No AC** (n = 430) |
Total* (n = 429) |
AC*** (n = 56) |
No AC*** (n = 373) |
* | ** | *** | |
| Oxygen requiring (%) | 264 (53.3%) | 34 (52.3%) |
230 (53.6%) | 192 (44.7%) |
26 (46.4%) |
166 (44.2%) |
0.0068 | 0.85 | 0.76 |
| ICU (%) | 171 (34.5%) | 20 (30.1%) |
151 (35.2%) | 58 (13.5%) |
5 (8.9%) |
53 (14.2%) |
0.0001 | 0.49 | 0.72 |
| Intubation (%) | 96 (19.4%) |
8 (12.3%) |
88 (20.5%) |
21 (4.9%) |
3 (5.4%) |
18 (4.8%) |
0.14 | 0.12 | 0.28 |
| PEEP (cm H20) (maximum) |
14 (10, 14) |
10 (8, 13) |
14 (10,15) |
8 (8, 12) |
8 (8, 16) |
9 (7,12) |
0.0009 | 0.01 | 0.86 |
| Prone positioning (ever) |
50 (52.1%) |
2 (3.1%) |
48 (11.2%) |
2 (8.3%) |
1 (1.8%) |
1 (0.3%) |
0.0001 | 0.04 | 0.24 |
| Shock requiring vasopressors (%) | 82 (16.6%) |
9 (13.8%) |
73 (17%) |
15 (3.5%) |
4 (7.1%) |
11 (2.9%) |
0.0001 | 0.13 | 0.11 |
| Bleeding (%) | 11 (2.2%) |
4 (6.1%) |
7 (1.6%) |
2 (0.5%) |
0 | 2 (0.5%) |
0.02 | 0.02 | 0.99 |
| Brain bleed (%) | 5 (1%) |
1 (1.5%) |
4 (0.9%) |
2 (0.5%) |
0 | 2 (0.5%) |
0.34 | 0.65 | 0.99 |
| Total VTE (%) | 22 (4.4%) |
1 (1.5%) |
21 (4.9%) |
4 (0.9%) |
1 (1.8%) |
3 (0.8%) |
0.001 | 0.22 | 0.99 |
| Pulmonary embolism(%) | 6 (1.2%) |
0 | 6 (1.9%) |
2 (0.5%) |
0 | 2 (0.3%) |
0.22 | 0.30 | 0.99 |
| Deep vein thrombosis | 20 (4%) |
1 (1.5%) |
19 (4.4%) |
4 (0.9%) |
1 (1.8%) |
3 (0.8%) |
0.003 | 0.27 | 0.99 |
| Other arterial Clot | 0 | 0 | 0 | 0 | 0 | 0 | 0.99 | 0.99 | 0.99 |
| Stroke | 4 (0.8%) |
1 (1.5%) |
3 (0.6%) |
1 (0.2%) |
0 | 1 (0.3%) |
0.99 | 0.48 | 0.99 |
| MI/New cardiomyopathy | 6 (1.2%) |
1 (1.5%) |
5 (1.2%) |
5 (1.2%) |
1 (1.8%) |
4 (1.1%) |
0.87 | 0.79 | 0.99 |
| Acute kidney injury | 215 (43.4%) | 31 (47.7%) |
184 (42.9%) | 126 (29.4%) |
17 (30.4%) |
109 (29.2%) |
0.0001 | 0.46 | 0.86 |
| Continuous renal replacement therapy | 15 (3%) |
3 (4.6%) |
12 (2.8%) |
5 (1.2%) |
1 (1.8%) |
4 (1.1%) |
0.16 | 0.43 | 0.99 |
| ICU length of stay (days) | 8 (3,18) |
4.5 (2, 14) |
9 (3, 19) |
6 (3,11) |
16 (2, 39) |
4 (3,10) |
0.48 | 0.3 | 0.28 |
| Hospital length of stay (days) | 8 (3,21) |
16 (7, 38) |
8 (3, 19) |
4 (2,7) |
5 (3, 8) |
4 (2,7) |
0.0001 | 0.007 | 0.34 |
| Death hospital | 79 (15.9%) |
17 (27.7%) |
62 (14.5%) |
22 (5.1%) |
4 (7.1%) |
18 (16.8%) |
0.0001 | 0.02 | 0.46 |
| Death within 90 days | 88 (17.8%) |
18 (29.2%) |
70 (16.3%) |
31 (7.2%) |
5 (8.9%) |
26 (7%) |
0.0001 | 0.02 | 0.59 |
Acute kidney injury was defined based on the Kidney Disease Improving Global Outcomes Clinical Practice Guidelines. Myocardial infarction was diagnosed when ST-elevation was present on electrocardiogram. Cardiomyopathy was diagnosed when an echocardiogram identified left ventricular ejection fraction <50%.
Anticoagulation (AC),Positive End-Expiratory Pressure (PEEP), Venous Thromboembolism (VTE), Myocardial Infarction (MI).