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In vitro detection of IgA in saliva. (A) Ig total levels in saliva determined by a direct detection method. The antibody titers in patients with severe, moderate, and no disease are represented. (B) The ΔIROP (%) corresponding to the specific anti-rS1 IgA antibody levels. Abbreviations: ΔIROP, difference in the increased relative optical power signal between the reference and after recognition of the biological event; rS1, recombinant SARS-CoV-2 spike protein; Ig, immunoglobulin.
