Figure 7.

Co-localization of AR, ESR1, and BCL6 enrichment with sDMRs and proposed working hypothesis. (a–c) Examples of overlapping sDMRs, sDEGs, BCL6, AR, or ESR1 enrichment; at female-biased sDMRs (a); and male-biased sDMRs (b and c). All tracks are shown in the context of the UCSC genome browser (mm10). BCL6-F1, BCL6-F3, and BCL6-F4 tracks show ChIP-seq peaks for BCL6 in the female liver (replicates 1, 3, and 4, respectively). BCL6-M1, BCL6-M2, and BCL6-M3 show ChIP-seq peaks for BCL6 in the male liver (replicates 1, 2, and 3, respectively)¹². The ESR1F track shows ChIP-seq peaks for ESR1 in the female liver, and the ARM track shows ChIP-seq peaks for AR in the male liver³⁰. The “sDMRs” track shows positions of sDMRs from the XX.F versus XY.M comparison based on WGBS data from⁶. The XX7, XX8, XX9, XY10, XY11, and XY12 liver tracks show positions of CG sites and the intensity of the tick reflects methylation level (WGBS data from⁶), in females (XX) and males (XY). (d) Schematic representation of the working hypothesis.