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. 2021 Jul 2;4:832. doi: 10.1038/s42003-021-02295-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a rs778798/rs17855739-defined FUT6 states. The expression states of FUT6 can be imputed from genotypes of rs778798 and rs17855739. The left panel displays the mean fluorescence values (MFI) of the CD15s staining of basophils in reference to the rs778798/rs17855739 genotype combination (null alleles are underlined; the inset shows the number of individuals with all genotype combinations detected in the SSIC cohort). The right panel shows the MFI of the CD15s staining vs. the imputed FUT6 status (+/+, +/−, −/−). Significance was determined by Kruskal–Wallis tests. b Impact of FUT6 status on the sLe^x expression on basophils. The type of CD15s basophil expression by a donor (CD15s^low, CD15s^bimodal, CD15s^high) can be described by the percentage of CD15s^high cells within the basophil population. The histogram shows the distribution of this parameter within the SSIC cohort. The data were grouped based on the imputed FUT6 status (blue: −/− (n = 12); red: +/− (n = 81); yellow: −/− (n = 122)). Insets show representative FACS histograms of the CD15s basophil staining for each FUT6 status. Bars are binned over a range of 5%.