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. 2021 Jul 2;12:4105. doi: 10.1038/s41467-021-24352-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematics indicating the location of SNP rs4561177 in human ZC3H12C. b Regulation of ZC3H12C expression by SNP rs4561177 was measured by a luciferase reporter system. The promoter region (~1 kb) containing the SNP was inserted upstream of the luciferase gene, and then transfected into 293 T cells for assessment of reporter activity (R.L.U) (n = 6 replicates). c ZC3H12C expression in psoriatic lesion (red) and non-lesions biopsies (blue) from psoriasis patients were analyzed (n = 28 individuals in GDS3539; n = 85 individuals in GDS4600). d ZC3H12C expression in psoriatic lesions after brodalumab treatment (GEO: GSE53552) was analyzed (n = 5 individuals for placebo, 8 individuals for brodalumab). e ZC3H12C expression in human peripheral blood mononuclear cells (PBMC) immune populations was measured by qPCR (n = 6 individuals for PMBC; n = 11 individuals for other groups). f Zc3h12c expression in murine WT immune populations was measured by qPCR (n = 3 mice per group). g Zc3h12c expression in sorted Zc3h12c ^fl/fl (blue) /Zc3h12c ^DCΔ (red) BM plasmacytoid dendritic cells (pDCs) was measured by qPCR after stimulation (n = 3 mice per group). h Zc3h12c expression in R848-treated Zc3h12c^+/+ (blue)/Zc3h12c^−/−(red) bone marrow-derived macrophages (BMDMs) was measured by qPCR at indicated timepoints (n = 3 mice per group). Data are representative at least three independent experiments (mean ± S.D.; two-tailed Student’s t test for murine samples; two-tailed Wilcoxon matched-pair signed rank test for human samples). Source data are provided as a Source Data file.