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. 2021 Jul 2;12:4086. doi: 10.1038/s41467-021-24049-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic representation of adjoining micrometer-sized sarcomeres within a myofibril, showing the organization of the thick (cyan) and thin (red) filaments in this basic contractile unit of striated muscle. Neonatal rat cardiomyocytes were labeled with antibodies specific for troponin T (TpnT; b, c), the heavy chain of myosin (Myosin; d, e), and α-actinin (f, g), respectively. Thin (b, c) and thick (d, e) filaments assemble into myofibrils, which align along the main axes of the star-like shaped cells and display regularly spaced Z-disks (f, g). Myofibril branching is indicated with white arrows. c, e, g Zoomed-in views of the framed regions in b, d, f, respectively. A minimum of three biologically independent experiments were performed in each case.