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. 2021 Jul 2;12(7):662. doi: 10.1038/s41419-021-03928-w

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Exosomes derived from the plasma of NSCLC patients with or without BoM were phenotyped (purity and shape) by transmission electron microscopy. Scale bar, 100 nm. B The size and particle count of the indicated exosomes with an LM10 nanoparticle characterisation system. Data are representative of three biological replicates. The representative pictures are presented. C Western blotting was performed to detect the expression of exosomal markers, CD9, CD63 and HSP70. Beta-actin was used as a reference protein. Data are representative of three biological replicates. D A real-time PCR assay was performed to determine the lncRNA-SOX2OT level in exosomes derived from the plasma of lung cancer patients with or without BoM. GAPDH was used as the internal control. E The Kaplan-Meier analysis was executed to determine the correlations between BoM and OS. F The Kaplan–Meier analysis was also performed to determine the correlations between the level of lncRNA-SOX2OT in exosomes and OS. *, P < 0.05; **, P < 0.01 (t test). Data are representative of three biological replicates.