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. 2021 Jul 2;11:13715. doi: 10.1038/s41598-021-93102-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Putative pleiotropic role of prokineticin 1 (PROK1) in the porcine trophoblast during the establishment of pregnancy. The IPA database was used to evaluate the functions of genes up-regulated and proteins activated by PROK1 (vehicle versus PROK1) in the porcine trophoblast collected on days 15 and 20 of pregnancy. The predicted activation is based on an absolute z-score > 2 and the P value of the gene overlap. The icons and color scheme are IPA defaults. Angiopoietin 2 (ANGPT2); cellular communication network factor 2 (CCN2); cadherin 13 (CDH13); fibroblast growth factor 2 (FGF2); fms-related receptor tyrosine kinase 1 (FLT1); kinase insert domain receptor (KDR); nuclear factor of activated T cells 2 (NFATC2); vascular endothelial growth factor A (VEGFA); phosphorylated mitogen-activated protein kinase 1/3 (pMAPK1/3); phosphorylated protein tyrosine kinase 2 (pPTK2); interferon gamma (IFNG); interleukin 1 beta (IL1B); interleukin 6 (IL6); interleukin 11 (IL11); LIF interleukin 6 family cytokine (LIF); LIF receptor subunit alpha (LIFR); tumor necrosis factor (TNF); biglycan (BGN); cadherin 1 (CDH1); fibroblast growth factor 9 (FGF9); insulin-like growth factor 1 (IGF1); matrix metallopeptidase 9 (MMP9); mucin 4 (MUC4); secreted phosphoprotein 1 (SPP1); transforming growth factor beta 3 (TGFB3); Wnt family member 4 (WNT4); Wnt family member 5A (WNT5A); Wnt family member 7A (WNT7A).