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. 2021 Jun 28;15:2815–2830. doi: 10.2147/DDDT.S281639

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© 2021 Stancil et al.

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(A) Intracellular activation pathway for nitroimidazoles. (B) Keto mycolic acid synthesis pathway. Pretomanid blocks formation of keto mycolic acids, a component of the cell wall, by impairing oxidation of precursor, hydroxymycolic acid.