Figure 3.

Summary of driver events in CRC evolution

Mutations and SCNAs were shown as frequency in patients indicating whether the events are clonal (blue) or subclonal (red). Only genes that were mutated in at least five patients in total or two patients in right-sided colon/left-sided colon/rectum were shown. For SCNAs, driver SCNAs in at least 20% of the patients were shown, while all the arm-level SCNAs were shown. A driver event (driver mutation, driver SCNA, or arm-level SCNA) was classified as a late event if it appeared more often as subclonal in patients than as clonal, otherwise it was an early event. In the arm-level SCNA part, “G” represented gain, “L” represented loss, and the numbers in parentheses represented the time of occurrence in tumors.