Figure 6.

Parallel evolution

(A) Genomic position and size of all mirrored subclonal allelic imbalance (MSAI) parallel gain or loss events found in this study. This included genome-wide copy number gains and losses which were subjected to MSAI events and their occurrence in CRC tumors.

(B) Parallel evolution of driver SCNAs observed in 5 CRC tumors, indicted by the depth ratio and B-allele frequency values of the same chromosome on which the driver SCNAs were located.

(C) Phylogenetic trees that indicated parallel evolution of driver amplifications (Amp) or deletions (Del) (Driver SCNAs) detected through the observation of MSAI (arrows).