Skip to main content
. 2021 Jun 11;297(1):100870. doi: 10.1016/j.jbc.2021.100870

Table 1.

List of the useful methods for protein structure prediction covered in this review with available links to access the resources

Multiple sequence alignment (MSA) construction
 PSI-BLAST https://blast.ncbi.nlm.nih.gov/Blast.cgi
 HHBlits Web server- https://toolkit.tuebingen.mpg.de/tools/hhblits
Downloadable version -https://github.com/soedinglab/hh-suite
 Jackhmmer https://www.ebi.ac.uk/Tools/hmmer/search/jackhmmer
 Hmmsearch https://www.ebi.ac.uk/Tools/hmmer/search/hmmsearch
 DeepMSA https://zhanglab.ccmb.med.umich.edu/DeepMSA/
Threading and Fold-recognition
 LOMETS https://zhanglab.dcmb.med.umich.edu/LOMETS/
 HHsearch https://github.com/soedinglab/hh-suite
 MUSTER https://zhanglab.dcmb.med.umich.edu/MUSTER/
 map_align https://github.com/sokrypton/map_align
 EigenTHREADER https://github.com/psipred/eigenthreader
 CEthreader https://zhanglab.dcmb.med.umich.edu/CEthreader/
 DisCovER https://github.com/Bhattacharya-Lab/DisCovER
 RaptorX http://raptorx.uchicago.edu
Full-length Structure Assembly for Template-Based Modeling (TBM)
 I-TASSER https://zhanglab.dcmb.med.umich.edu/I-TASSER/
 MODELLER https://salilab.org/modeller/
 RosettaCM https://www.rosettacommons.org/software/license-and-download
 SWISS-MODEL https://swissmodel.expasy.org/
 Phyre2 http://www.sbg.bio.ic.ac.uk/phyre2/
Fragment Assembly Simulation Methods for Free Modeling (FM)
 Rosetta Web server: https://robetta.bakerlab.org
Downloadable version: https://www.rosettacommons.org/software/license-and-download
 QUARK https://zhanglab.dcmb.med.umich.edu/QUARK/
 FragFold https://github.com/psipred/fragfold
Co-evolution and Deep Learning-Based Contact/Distance Prediction
 PSICOV http://bioinfadmin.cs.ucl.ac.uk/downloads/PSICOV/
 CCMpred https://github.com/soedinglab/CCMpred
 GREMLIN http://gremlin.bakerlab.org
 NeBcon https://zhanglab.dcmb.med.umich.edu/NeBcon/
 MetaPSICOV http://bioinf.cs.ucl.ac.uk/psipred/
 ResPRE https://zhanglab.dcmb.med.umich.edu/ResPRE/
 TripletRes https://zhanglab.ccmb.med.umich.edu/TripletRes/
 RaptorX-Contact http://raptorx.uchicago.edu/ContactMap/
 MSA Transformer https://github.com/facebookresearch/esm
Deep Learning-Based Full-length Structure Prediction
 AlphaFold https://github.com/deepmind/
 D-I-TASSER https://zhanglab.dcmb.med.umich.edu/D-I-TASSER/
 D-QUARK https://zhanglab.dcmb.med.umich.edu/D-QUARK/
 trRosetta https://yanglab.nankai.edu.cn/trRosetta/
 DMPfold Web server - http://bioinf.cs.ucl.ac.uk/psipred/
Downloadable version https://github.com/psipred/DMPfold