Table 2.

Summary of the current state-of-the-art structure prediction methods, including their results in the most recent CASP experiment and their web server URL addresses

Method	CASP14 group name	CASP14 resultsa	Description; URL address
D-I-TASSER	Zhang-Server	First Place Server	Template and deep learning distance/orientation/hydrogen bond network-guided folding; https://zhanglab.dcmb.med.umich.edu/D-I-TASSER/
D-QUARK	QUARK	Second Place Server	Deep learning distance/orientation-guided folding; https://zhanglab.dcmb.med.umich.edu/D-QUARK/
AlphaFold2	AlphaFold2	First Place Human Group	End-to-end deep learning-based model prediction; https://github.com/deepmind/
Rosetta	BAKER	Second Place Human Group	Deep learning distance/orientation-guided folding; Robetta Server: https://robetta.bakerlab.org trRosetta Server: https://yanglab.nankai.edu.cn/trRosetta/

^aMethods in CASP are divided into server and human groups. Predictions by server groups are fully automated, whereas those by human groups do not have to be.