Figure 7.

Schematic representation of chromosomal abnormalities visualized after FISH assay

(A) Schematic representation at genomic level of a control diploid cell containing a pair of chromosomes, and its corresponding normal FISH signal pattern is illustrated in the second column (Top).

(B) (Top) Schematic representation of the amplification of a specific targeted locus. Gene amplification can be observed both at genomic level and through FISH signaling pattern. (Bottom) Schematic representation of locus deletion, upon chromosome breaks. Gene deletion can be observed both at genomic level and through FISH signaling pattern.

(C) Polyploidy where the probe signal shows multiple sets of chromosomes, observed by three pair of fused genes.