Fig. 3.

A: Violin plot of mean shortest PPI distances to doxorubicin target. Red bars represent the mean PPI distance of the cis-eQTL genes to doxorubicin target genes, doxorubicin related enzymes, doxorubicin related enzymes/carriers/transporters, and doxorubicin-interacting genes. Blue bars represent the mean shortest PPI distance of 10,000 groups of randomly selected genes. B: ROC curve for the predictive performance of the LDA genomic pCR predictor with these eQTL genes as features. C: Volcano plot of univariate cox proportional hazards results of eQTL genes. Horizontal axis showed the univariate cox proportional hazards confidences and vertical axis showed the negative log of the P values. Doxorubicin-resistant genes are shown on upper and doxorubicin-sensitive genes are shown on below. D: Volcano plot of univariate cox proportional hazards results of PAS of enriched pathways. Horizontal axis shows the univariate cox proportional hazards confidences and vertical axis showed the negative log of the P values. Positive pathways are shown on upper and negative pathways are shown on below. E: Univariate cox proportional hazards confidences of 6 positive pathways had significant risk PAS and 7 negative pathways had significant protective PAS. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)