Fig. 6.

Stem cell markers were involved in RILI. A Nitric oxide synthase 3, endothelial (eNOs) level in mouse serum. Serums were collected after 3, 7 and 14 days after radiation treatment. n = 3. B Nitric oxide (NO) level in mouse serum. Serums were collected after 3, 7 and 14 days after radiation treatment. n = 3. C–F Representative IHC staining images of cMyc, Klf4, Oct3/4 and Sox2 after radiation damage in SOX9^CreER; Rosa^DTA mice and control mice (left). The IHC staining scores of cMyc, Klf4, Oct3/4 and Sox2 were assessed (right). *p < 0.05, **p < 0.01, ***p < 0.001 and ***p < 0.0001 as determined by unpaired Student’s t test. n = 3. Scale bar, 50 μm