Table 1.
Proteins displaying most affected binding to mRNA subsequent to MMS treatment
| Gene | Protein name | Anova | t-test significance | Median log2 SILAC ratios |
||||
|---|---|---|---|---|---|---|---|---|
| 0 h | 4 h | 15 h | 0 h | 4 h | 15 h | |||
| Significant differential binding | ||||||||
| ZC3HAV1 | Zinc-finger CCCH-type antiviral protein 1 | + | + | − 0.51 | − 0.52 | − 0.19 | ||
| SND1 | Staphylococcal nuclease domain-containing protein 1 | + | + | − 1.03 | − 0.04 | − 0.22 | ||
| HDLBP | Vigilin | + | − 0.65 | − 0.11 | − 0.16 | |||
| ZC3H8 | Zinc finger CCCH domain-containing protein 8 | + | − 0.77 | − 0.23 | 0.27 | |||
| SERBP1 | Plasminogen activator inhibitor 1 RNA-binding protein | + | + | − 1.10 | − 0.05 | − 0.06 | ||
| NSUN2 | tRNA (Cytosine(34)-C(5))-methyltransferase | + | + | − 0.19 | 0.15 | 0.59 | ||
| RPSA | 40S ribosomal protein SA | + | + | − 0.58 | − 0.05 | 0.05 | ||
| RPS3 | 40S ribosomal protein 3 | + | + | − 0.93 | − 0.08 | 0.00 | ||
| RPS10 | 40S ribosomal protein 10 | + | − 0.74 | 0.03 | 0.07 | |||
| RPS14 | 40S ribosomal protein 14 | + | + | − 0.91 | − 0.07 | − 0.05 | ||
| RPS26P11 | Putative 40S ribosomal protein S26-like 1 | + | − 0.81 | − 0.08 | 0.05 | |||
| Sub-significantly increased binding | ||||||||
| ASCC3 | Activating signal cointegrator 1 complex subunit 3 | 0.72 | − 0.02 | 0.21 | ||||
| YTHDC2 | Probable ATP-dependent RNA helicase YTHDC2 | 0.56 | 0.03 | − 0.01 | ||||
| TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25 | 0.80 | 0.05 | 0.06 | ||||
| GEMIN5 | Gem-associated protein 5 | 0.62 | 0.78 | 0.50 | ||||