Fig. 4.

MSCs-Exo-miR-26a-5p mimic attenuated ischemia–reperfusion injury in MCAO/R model. Mice were treated with MCAO/R, and injected with 200 μL/mice MSCs-exosomes-miR-NC or MSCs-exosomes-miR-26a-5p mimics. A The mRNA level of miR-26a-5p in brain tissues was evaluated qRT-PCR. B Representative brain sections of MCAO/R induced mice were detected by TTC staining. C TUNEL staining in brain tissues. D The protein level of apoptosis-related markers (cleaved caspase-3, total caspase-3, cleaved RARP and total RARP) in brain tissues was detected by western blot. *p < 0.05, **p < 0.01, ***p < 0.001