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. 2021 Jul 2;19:196. doi: 10.1186/s12951-021-00939-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — RGD-PEI/SAA reduced neovascularization in laser-induced CNV mice model. a Representative eye fundus photographs of BF (bright field) and FA (fluorescein angiography) obtained on Day 0 and Day 7 after laser injury with intravitreal injection of PBS or RGD-PEI/SAA (2.5 µM, 2 µL/eye). b Representative images of isolectin B4 staining laser-induced CNV RPE/choroid/sclera flat mounts after intravitreal injection of PBS (1), mPEI (2), RGD-PEI (3), SAA (4), mPEI/SAA (5) and RGD-PEI/SAA (6) at an SAA concentration of 20 µM, 2 µL/eye. Scale bar = 100 µm. c Quantitative analysis of the average CNV area (mm²) in each group (n = 28). Error bar stands for the standard error of the mean (** for p < 0.01, **** for p < 0.0001)