Table 1.
Characteristics of the Development Cohort and Validation Cohort
| Variables | Total | Development Cohort | Validation Cohort | P value |
|---|---|---|---|---|
| No. of participants | 3659 | 2744 | 915 | |
| Age (years) | 44.76 ± 15.55 | 44.83 ± 15.57 | 44.57 ± 15.50 | 0.671 |
| Gender (n, %) | 0.372 | |||
| Female | 1649 (45.07%) | 1225 (44.64%) | 424 (46.34%) | |
| Male | 2010 (54.93%) | 1519 (55.36%) | 491 (53.66%) | |
| DBP (mmHg) | 72.98 ± 10.28 | 73.12 ± 10.29 | 72.54 ± 10.24 | 0.137 |
| SBP (mmHg) | 121.94 ± 17.59 | 122.29 ± 17.75 | 120.90 ± 17.07 | 0.062 |
| BMI (kg/m2) | 21.35 ± 2.06 | 21.37 ± 2.03 | 21.31 ± 2.14 | 0.488 |
| LDL-c (mmol/L) | 2.14 ± 0.43 | 2.14 ± 0.43 | 2.11 ± 0.43 | 0.032 |
| HDL-c (mmol/L) | 1.52 ± 0.30 | 1.51 ± 0.29 | 1.53 ± 0.31 | 0.104 |
| TG (mmol/L) | 1.01 ± 0.30 | 1.01 ± 0.30 | 1.00 ± 0.30 | 0.425 |
| TC (mmol/L) | 4.34 ± 0.54 | 4.35 ± 0.54 | 4.32 ± 0.53 | 0.195 |
| FPG (mmol/L) | 5.23 ± 0.82 | 5.24 ± 0.83 | 5.19 ± 0.82 | 0.101 |
| UA (μmol/L) | 272.72 ± 84.69 | 274.36 ± 83.22 | 267.79 ± 88.82 | 0.042 |
| Cr (μmol/L) | 83.27 ± 30.84 | 83.43 ± 31.34 | 82.79 ± 29.30 | 0.588 |
| BUN (mmol/L) | 4.62 ± 1.54 | 4.65 ± 1.52 | 4.56 ± 1.59 | 0.129 |
| DBIL (mmol/L) | 2.33 ± 1.20 | 2.34 ± 1.20 | 2.31 ± 1.19 | 0.507 |
| TB (mmol/L) | 12.23 ± 5.00 | 12.25 ± 5.00 | 12.17 ± 4.98 | 0.699 |
| GLB (U/L) | 29.31 ± 4.15 | 29.32 ± 4.21 | 29.30 ± 3.96 | 0.916 |
| ALB (U/L) | 44.30 ± 2.75 | 44.31 ± 2.74 | 44.26 ± 2.78 | 0.588 |
| TP (U/L) | 73.61 ± 4.36 | 73.63 ± 4.37 | 73.56 ± 4.31 | 0.659 |
| AST (U/L) | 22.73 ± 9.38 | 22.68 ± 9.50 | 22.86 ± 9.02 | 0.621 |
| ALT (U/L) | 16.00 (12.00–21.00) | 16.00 (12.00–21.00) | 16.00 (12.00–22.00) | 0.605 |
| GGT (U/L) | 20.00 (15.00–27.00) | 20.00 (16.00–27.00) | 20.00 (15.00–28.00) | 0.121 |
| ALP (U/L) | 70.73 ± 22.75 | 70.86 ± 23.12 | 70.35 ± 21.60 | 0.559 |
| Follow-up (days) | 720.00 (658.00–1061.00) | 721.00 (658.00–1063.00) | 715.00 (656.00–1048.00) | 0.121 |
| Incident NAFLD (n, %) | 0.974 | |||
| No | 3202 (87.51%) | 2401 (87.50%) | 801 (87.54%) | |
| Yes | 457 (12.49%) | 343 (12.50%) | 114 (12.46%) |
Notes: Data are n (%), mean ± SD or median (interquartile range).
Abbreviations: BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; ALP, alkaline phosphatase; GGT, γ-glutamyltranspeptidase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TP, total protein; ALB, albumin; GLB, globulin; TB, total bilirubin; DBIL, direct bilirubin; BUN, blood urea nitrogen; Cr, creatinine; UA, uric acid; FPG, fasting plasma glucose; TC, total cholesterol; TG, triglyceride; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; NAFLD, non-alcoholic fatty liver disease.