Table 5. Kyoto Encyclopedia of Genes and Genomes Orthology (KO) terms with differential abundances between baseline and week 4 (n = 28, |fold change| ≥ 2 and adjusted p < 0.05).
| KO term | Description | Week 4 vs. Baseline | |
|---|---|---|---|
| Log 2 FC mean ± SE |
Adjusted P−value1 |
||
| Increased abundance at week 4 | |||
| K16323 | purine nucleoside transport protein | 7.2 ± 1.24 | 1.80E−05 |
| K13548 | 2-deoxy-scyllo-inosamine dehydrogenase [EC:1.1.1.329] | 6.29 ± 1.39 | 0.005 |
| K11628 | mycocerosic acid synthase [EC:2.3.1.111] | 5.99 ± 1.58 | 0.034 |
| K20707 | lysine racemase [EC:5.1.1.5] | 5.91 ± 1.62 | 0.046 |
| K16959 | L-cystine transport system permease protein | 4.95 ± 1.15 | 0.009 |
| K00638 | chloramphenicol O-acetyltransferase type B [EC:2.3.1.28] | 4.45 ± 1.14 | 0.025 |
| K16846 | (2R)-sulfolactate sulfo-lyase subunit beta [EC:4.4.1.24] | 3.97 ± 0.97 | 0.016 |
| K03457 | nucleobase:cation symporter-1, NCS1 family | 3.32 ± 0.72 | 0.004 |
| K12442 | phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase C [EC:2.3.1.292] | 3.13 ± 0.85 | 0.045 |
| K12953 | cation-transporting P-type ATPase F [EC:7.2.2.-] | 3.07 ± 0.79 | 0.025 |
| K19279 | aminoglycoside 9-adenylyltransferase [EC:2.7.7.-] | 2.66 ± 0.63 | 0.009 |
| K18104 | ATP-binding cassette, subfamily B, bacterial AbcA/BmrA [EC:7.6.2.2] | 2.65 ± 0.68 | 0.025 |
| K19422 | glycosyltransferase EpsD [EC:2.4.-.-] | 2.32 ± 0.59 | 0.025 |
| K15125 | filamentous hemagglutinin | 1.91 ± 0.53 | 0.048 |
| Decreased abundance at week 4 | |||
| K13925 | plasmin and fibronectin-binding protein A | −8.43 ± 1.90 | 0.006 |
| K02203 | phosphoserine / homoserine phosphotransferase [EC:3.1.3.3 2.7.1.39] | −5.08 ± 1.03 | 0.001 |
| K13532 | two-component system, sporulation sensor kinase D [EC:2.7.13.3] | −4.17 ± 1.15 | 0.047 |
| K09759 | nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23] | −4.06 ± 0.78 | 0.000 |
| K00351 | Na+−transporting NADH:ubiquinone oxidoreductase subunit F [EC:7.2.1.1] | −3.88 ± 0.95 | 0.016 |
| K14136 | decaprenyl-phosphate phosphoribosyltransferase [EC:2.4.2.45] | −3.33 ± 0.87 | 0.030 |
| K16165 | fumarylpyruvate hydrolase [EC:3.7.1.20] | −2.97 ± 0.79 | 0.036 |
| K16011 | mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase [EC:2.7.7.13 5.3.1.8] | −2.65 ± 0.63 | 0.011 |
| K13019 | UDP-GlcNAc3NAcA epimerase [EC:5.1.3.23] | −2.01 ± 0.54 | 0.040 |
| K17716 | UDP-glucose 4-epimerase [EC:5.1.3.2] | −1.72 ± 0.46 | 0.034 |
| K00385 | anaerobic sulfite reductase subunit C | −1.64 ± 0.38 | 0.008 |
Notes:
1
P values were adjusted with false discovery rate for multiple comparisons.