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. 2021 Jun 29;14:2943–2954. doi: 10.2147/DMSO.S311462

Table 3.

Associations Between Changes in the 12-Month Follow-Up Period in HRQoL, BMI, and RTWSE with WAS in Combination with Work Absence and RTWEXP, Adjusted for the Background Variables. Unadjusted and Adjusted Multiple Regression Analyses

Unadjusted Analysis p values Intermediate Analysis p values Final Analysis p values
Ba 95% CI B 95% CI B 95% CI
Age 0.03 −0.03: 0.1 0.335
Gender
 Male 0 0 0
 Females −0.64 −1.99: 0.61 0.311 −0.88 −1.88:0.11 0.081 −0.55 −1.56: 0.46 0.283
Sick leave diagnosis 0.067 0.090 0.214
 MS b 0 0 0
 EMDc 1.82 0.29: 3.35 0.021 1.18 0.17:2.53 0.086 1.13 −0.14: 2.40 0.079
 All otherd 0.66 −0.77:2.08 0.362 −0.22 −1.43:0.96 0.696 0.29 −1.83: 0.36 0.184
Educational level (years) 0.117 0.144 0.05
 College/university (>14) 0.48 −0.82: 1.78 0.460 −1.00 −2.08:0.08 0.067 −0.73 −1.83: 0.36 0.184
 High school (<13) 0 0 0
 Elementary school (<10) −1.74 −3.88: 0.39 0.108 −1.24 −3.14:0.67 0.198 −2.04 −3.71: −0.36 0.018
WASe 0.40 0.18: 0.62 0.001 0.55 0.27:0.83 <0.001 0.49 0.28: 0.71 <0.001
HRQoLf 0.19 0.07: 0.31 0.003 0.31 0.17:0.44 <0.001 0.27 0.16: 0.38 <0.001
BMIf −0.03 −0.25: 0.18 0.749
RTWSEf 0.01 0.00: 0.03 0.026 0.00 −0.01:0.01 0.737
RTWEXPe −0.38 −0.71: −0.05 0.025 0.20 −0.19:0.58 0.305
Work absence daysg −0.01 −0.01: −0.00 0.004 0.00 −0.01:0.01 0.570

Notes: Univariate and intermediate analyses. p values less than 0.20 are marked with bold and further included in the intermediate analyses. Multiple regression analysis: Intermediate and final analyses are controlled for the effect of background variables and HRQoL baseline. aUnstandardized regression coefficient (B). bMusculoskeletal diagnosis. cEndocrine, metabolic, and nutritional diagnosis. dAll other reported diagnosis. eValue of baseline. fValue of change from baseline to 12 months. gWork absence, measured as the number of days 1 year before baseline. In the final analyses, statistically significant p values (≤ 0.05) marked in bold. R2 = 0.49 for final analysis.