Table 1.

Assessment of Liver Fibrosis Severity According to Studies’ Designs

Liver Disease Severity	Tool for Staging	Authors
Cirrhosis
Histology	METAVIR F4	Conti,8 Cabibbo,13 Calvaruso,20 Degasperi,22 Nahon,21 Pol,23 Ravaioli,25 Degasperi,26 Rinaldi,27 Lleo,28 Degapseri,31 Finkelmeier,35 Pinero,39 Tanaka,42 Alonso Lopez,45 Tamaki48*, Nagata,54 Kogiso65
Clinical	Any clinical features	Cabibbo,13 Calvaruso,20 Degasperi,22 Ravaioli,25 Rinaldi,27 lleo,28 Degasperi,26 Degasperi,31 Sangiovanni,32 Ogawa,38 Alonso Lopez,45 Kwon,51 Ogawa,55 Kogiso,65 Zou67
	US features
FIB-4	>3.25	Tanaka,42 Nagata54
	Not specified	Ide40
LSM	≥12 kPa	Conti,8 Bergna,30 Sangiovanni,32 Ogasawara57
	>12 kPa	Cabibbo,13 Calvaruso,20 Casadei-Gardini29
	>12.5 kPa	Ravaioli,25 Lleo,28 Finkelmeier,35 Virlogeux61
	≥12.5 kPa	Pinero,39 Tanaka,42 Seholm53
	≥ 13.5 kPa	Rinaldi27
	≥14.9 kPa	Ogawa38
	>16.2 kPa	Bergna,30 Shiha44
	Not specified	Rinaldi,36 Ogawa55
ICD codes		Kanwal,34 Kanwal,41 Zou67
Advanced fibrosis
Histology	METAVIR F3-F4	Nagata54
LSM	>9.5 kPa	Pinero,39 Alonso Lopez45
	>10 kPa	Ogawa38
	≥10 kPa	Pons,46 Seholm53
	>10.2 and ≤16.2 kPa	Shiha44
FIB-4	>3.25	Tani,52 Nagata,54 Watanabe59
APRI	≥1	Watanabe59

Notes: *Available in 191 out of 346 patients.

Abbreviations: F, fibrosis; US, ultrasound; FIB-4, fibrosis-4 index; LSM, liver stiffness measurement; APRI, AST to platelet ratio; ICD, international classification of diseases (code).