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. 2021 Jun 29;8:685–699. doi: 10.2147/JHC.S296234

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© 2021 Wang et al.

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Knockdown of SIRT1 suppresses self-renewal of liver CSCs. (A) Proliferation efficiency was detected in liver CSCs after knockdown of SIRT1 by EdU assay. (B) Graph showed the quantification of EdU-positive cells. (C-D) Colony formation efficiency was determined in liver CSCs after SIRT1 inhibition. (E-F) Sphere formation efficiency was determined in liver CSCs after knockdown of SIRT1. (G-H) SIRT1-inhibition in liver CSCs reduced their resistance to sorafenib and cisplatin. All values presented as mean ± S.D. *p < 0.05, **p < 0.01. Scale bar, 100 µm.