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. 2021 Jun 29;8:685–699. doi: 10.2147/JHC.S296234

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© 2021 Wang et al.

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Decreased SIRT1 expression induces cellular senescence of CSCs in tumor tissues. (A) Representative images for SA-β-Gal activity in formed tumor after SIRT1 knockdown. (B) Expression of p21 was detected in tumor sections by IHC staining. (C) Graph showed the quantification of p21-positive cells. (D) IHC staining was used to determine the expression of Ki67 in tumor sections. (E) Graph showed the percentage of Ki67-positive nuclei in tumor sections. All values presented as mean ± S.D. **p < 0.01. Scale bar, 100 µm.