Figure 3.

Current–voltage (I–V) relationships for α,β-meATP with or without the pre-application of TNF-α. (A) Original currents show that TNF-α (10 ng/mL) pretreatment increased the currents induced by 100 μM α,β-meATP at three different holding potentials. (B) The graph shows the effect of TNF-α (10 ng/mL) pretreatment on I–V curves for α,β-meATP. All current values were normalized to the current response induced by 100 μM α,β-meATP applied alone at −60 mV holding potential (marked with asterisk). Each point represents the mean ± SEM of 7–9 neurons. This experiment was carried out using recording pipettes filled with CsCl containing internal solution.