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. 2021 Jun 29;14:2841–2850. doi: 10.2147/JIR.S315774

Figure 4.

Figure 4

p38MAPK, but not COX, was involved in the potentiation of P2X3 receptor-mediated ATP currents by TNF-α. Representative current traces in (A) and the bar graph in (B) showed that the effects of TNF-α alone, p38 inhibitor SB202190 plus TNF-α, and non-selective COX inhibitor indomethacin plus TNF-α on α,β-meATP (100 μM) -evoked currents. IATP was significantly enhanced by TNF-α (10 ng/mL, 5 min) pre-treatment alone or combined treatment of indomethacin (30 μM, 3+5=8 min) plus TNF-α (10 ng/mL, 5 min). However, the enhancement of IATP did not occur when DRG cells were treated with SB202190 (10 μM, 3+5=8 min) plus TNF-α (10 ng/mL, 5 min). Statistical tests were performed using one-way ANOVA followed by post hoc Bonferroni’s test, and significance is shown **P < 0.01. n.s. Not significant. n = 7 in each column.