Table 4.
Patients Listed for Transplant with HCV and HCC (Second Study Cohort) and Their Waiting List Outcomes
| Number (%) | Raw P value | Bonferroni Adjusted P value | ||
|---|---|---|---|---|
| IFN-Based DAA Treatment Era | IFN-Free DAA Treatment Era | |||
| Patients actively on the waiting list at any time during each era | 6226 | 6293 | ||
| Patients transplanted regardless of explant form generated | 2988 (47.99) | 3206 (50.94) | <0.01 | <0.01 |
| Actively on the waiting list on the last day of each era (did not receive an organ) | 1777 (28.54) | 1402 (22.28) | <0.01 | <0.01 |
| Total dropout | 1461 (23.47) | 1685 (26.78) | <0.01 | <0.01 |
| Analysis of dropout patients a | ||||
| Patients died while waiting for an organ | 824 (56.40) | 737 (43.74) | <0.01 | 0.15 |
| Patients deteriorated (transplant not indicated) | 180 (12.32) | 349 (20.71) | <0.01 | <0.01 |
| Patients improved (transplant not indicated) | 23 (1.57) | 44 (2.61) | 0.01 | 0.17 |
| Patients lost to follow-up | 13 (0.89) | 28 (1.66) | 0.02 | 0.31 |
| Otherb | 421 (28.82) | 527 (31.28) | ||
Notes: aNumbers and percentages are calculated from the total dropout number. bPatients were removed from the waiting list because of refusal of transplant, transfer to other center or country, multiple listing, in error, or unspecified reason.
Abbreviation: DAA, direct-acting antiviral.