. 2021 Jun 29;14:19–25. doi: 10.2147/SCCAA.S312929

Table 1.

Growth Characteristics of Colonic Epithelial Cells

Cell Line	Biomarker
	Genotype		Population Doubling Time^a (hr.)	Saturation Density^a (x10⁵)	AI Colonies^b(number)
	Mlh1	Apc	Population Doubling Time^a (hr.)	Saturation Density^a (x10⁵)	AI Colonies^b(number)
C57 COL	+/+	+/+	34.0±3.9	7.8±0.2	0.8±0.5
Mlh₁/1638N COL-Cl₁	-/-	-/-	17.0±1.6	21.0±1.2	15.2±1.4
P			0.041	0.010	0.001
Relative to C57 COL			−50.0%	+1.69X	+18.0X

Notes: ^aDetermined at 7 post-seeding of 1.0x10⁵cells, mean ± SD, n=3 per treatment group. ^bDetermined at day 14 post-seeding of 100 cells, mean ±SD, n=18 per treatment group. Data analyzed by two-sample student’s t test.

Abbreviations: AI, anchorage independent; SD, standard deviation; X, fold change.