Table 2.
Composites, Predictors, Covariates for Cancer Recurrence from Cox Proportional Hazards Regression Models Analyses
| Adjusted for in Multivariate Analyses Variable |
3 Level Composite | 2 Level Composite | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumour Volume % > 8% | Tumour Volume % > 8% | ||||||||||||||
| LNI | Stage T3 | ||||||||||||||
| (1) Tumour Volume % > 8% | (2) Stage T3 | (3) Positive surgical margin | (4) Positive surgical margin |
(5) Gleason: Low | (6) Gleason: Inter- mediate | (7) Gleason: High | (8) Positive surgical margin | (9) Stage T2 |
(10) LNI | (11) Stage T3 | (12) Gleason: Low | (13) Gleason: Inter-mediate | (14) Gleason: High | ||
| Predictors | |||||||||||||||
| See column header (1 to 14) | 1.61 (1.11, 2.48) 0.001 | 3.73 (2.27, 6.14) <0.001 | 2.68 (1.50, 4.77) 0.001 | 1.66 (1.06, 2.59) 0.026 | 1.01 (0.31, 3.23) 0.991 | 1.55 (1.02, 2.35) 0.042 | 1.95 (1.11, 3.44) 0.021 | 1.60 (1.09, 2.35) 0.017 | 1.15 (0.79, 1.68) 0.464 | 2.69 (1.64, 4.40) <0.001 | 1.85 (1.23, 2.80) 0.003 | 0.75 (0.42, 1.33) 0.319 | 1.60 (1.13, 2.27) 0.008 | 1.52 (0.94, 2.47) 0.089 | |
| Covariates | |||||||||||||||
| PSA (units = 10%) | 1.04 (0.99, 1.08) 0.130 | 1.03 (0.97, 1.09) 0.359 | 1.04 (0.98, 1.10) 0.237 | 1.04 (0.98, 1.11) 0.200 | 1.03 (0.97, 1.10) 0.281 | 1.02 (0.97, 1.08) 0.418 | 1.04 (0.98, 1.11) 0.178 | 1.03 (0.97, 1.10) 0.297 | 1.04 (0.98, 1.10) 0.217 | 1.03 (0.98, 1.10) 0.304 | 1.03 (0.97, 1.10) 0.317 | 1.03 (0.97, 1.09) 0.359 | 1.02 (0.96, 1.08) 0.503 | 1.04 (0.98, 1.10) 0.255 | |
| Age (years) | 1.00 (0.98, 1.01) 0.457 | 1.02 (0.99, 1.05) 0.122 | 1.02 (1.00, 1.05) 0.098 | 1.02 (0.99, 1.04) 0.264 | 1.01 (0.99, 1.04) 0.294 | 1.02 (0.99, 1.04) 0.164 | 1.01 (0.99, 1.04) 0.306 | 1.02 (0.99, 1.05) 0.177 | 1.01 (0.99, 1.04) 0.299 | 1.02 (0.99, 1.05) 0.118 | 1.02 (0.99, 1.05) 0.164 | 1.02 (0.99, 1.05) 0.146 | 1.03 (1.00, 1.05) 0.063 | 1.02 (0.99, 1.04) 0.209 | |
| Significant Predictors | |||||||||||||||
| Pathological Gleason score (sum) | 1.18 (1.03, 1.36) 0.039 | 1.31 (1.09, 1.59) 0.005 | 1.38 (1.14, 1.67) 0.001 | 1.37 (1.13, 1.66) 0.001 | 1.29 (1.07, 1.57) 0.009 | 1.35 (1.11, 1.62) 0.002 | 1.28 (1.06, 1.56) 0.012 | 1.27 (1.05, 1.54) 0.016 | |||||||
| Positive surgical margin | 1.28 (1.11, 1.62) 0.018 | 1.57 (1.10, 2.25) 0.014 | 1.95 (1.39, 2.74) <0.001 | 1.80 (1.27, 2.55) 0.001 | 1.80 (1.27, 2.55) 0.001 | 1.79 (1.26, 2.55) 0.001 | 1.51 (1.04, 2.18) 0.029 | 1.51 (1.04, 2.19) 0.031 | 1.69 (1.18, 2.43) 0.004 | 1.61 (1.12, 2.30) 0.009 | 1.57 (1.09, 2.27) 0.015 | ||||
| Pathological stage | Stage T2 (Reference) | ||||||||||||||
| Stage T3 | 1.73 (1.33, 2.26) <0.001 | 1.73 (1.19, 2.51) 0.004 | 1.54 (1.05, 2.27) 0.027 | 1.48 (1.00, 2.19) 0.053 | 1.60 (1.09, 2.35) 0.017 | 1.50 (1.02, 2.21) 0.039 | 1.64 (1.12, 2.40) 0.011 | ||||||||
| Lymph node invasion (binary: yes vs no vs not removed) | No (Reference) | ||||||||||||||
| Yes | 1.36 (1.02, 1.99) 0.039 | 2.20 (1.29, 3.74) 0.004 | 2.73 (1.65, 4.50) <0.001 | 2.39 (1.43, 3.99) 0.001 | 2.39 (1.43, 4.01) 0.001 | 2.06 (1.22, 3.48)0.007 | 2.47(1.47, 4.15) 0.001 | 1.96 (1.15, 3.34) 0.013 | 2.33 (1.41, 3.87) 0.001 | 2.32 (1.40, 3.86) 0.009 | 2.19 (1.30, 3.67) 0.003 | ||||
| LN not removed | 0.88 (0.66, 1.18) 0.409 | ||||||||||||||
Notes: Model: Cox proportional hazards regression; Outcome = recurrence; Estimates: Hazard Ratios (95% CI), and p-value, adjusted multivariate estimates.