Table 5.

Subgroups Analyses

	Mild vs Severe	Mild vs Critical	Severe vs Critical
	p*	p*	p*
Age (years)	<0.001	<0.001	0.002
Cigarettes (packs/year)	<0.001	0.016	0.790
Hematological Parameters
WBC (10^3/uL)	0.052	0.248	0.040
Hemoglobin (g/dL)	0.063	0.001	0.007
Neutrophil (10^3/uL)	0.085	0.001	0.013
Lymphocyte (10^3/uL)	<0.001	<0.001	<0.001
Thrombocyte (10^3/uL)	0.046	0.009	0.084
Biochemical Parameters
CRP (mg/L)	<0.001	<0.001	<0.001
Procalcitonin (µg/L)	0.008	<0.001	<0.001
Lactate dehydrogenase (U/L)	<0.001	<0.001	0.001
Creatinine (mg/dl)	<0.001	<0.001	<0.001
Albumin (g/L)	<0.001	<0.001	<0.001
D-dimer (µg/L)	<0.001	<0.001	0.001
Ferritin (µg/L)	0.001	<0.001	0.132
Troponin (pg/mL)	<0.001	<0.001	0.001
Fibrinogen (mg/dl)	0.001	0.002	0.194
NLR	<0.001	<0.001	<0.001
CRP/Albumin Ratio	<0.001	<0.001	<0.001
Vital Signs
Respiratory rate (breaths/min)	<0.001	<0.001	<0.001
Heart Rate (beats/min)	0.644	<0.001	<0.001
Body temperature (°C)	0.007	<0.001	<0.001
Risk Score
CURB-65	<0.001	<0.001	<0.001

Note: *Subgroup analyses (mild vs severe, mild vs critical, and severe vs critical) were conducted using chi-squared and the Mann–Whitney U-tests, as appropriate.

Abbreviations: WBC, white blood cell; NLR, neutrophil–lymphocyte ratio; CRP, C-reactive protein; CURB-65 (new-onset confusion, blood urea nitrogen > 42.8 mg/dL, respiratory rate > 30 breaths/min, blood pressure < 90/60 mmHg, age ≥ 65 years)