Table 1.
Association between 52 SNPs and circulating CRP concentrations identified in Ligthart et al. (11) and between SNPs-and CRC-specific survival associations in ISACC
| rs | chr: pos* | Count/ Alternative allele | Count allele freq | Ligthart et al. SNP-CRP associations | ISACC SNP-survival associations | ||||
|---|---|---|---|---|---|---|---|---|---|
| beta** | se | P | HD*** (per 100,000 person year) | se | P | ||||
| rs2293476 | 1:40036847 | C/G | 0.23 | 0.030 | 0.004 | 8.27E-13 | 0.124 | 3.44E-06 | 0.72 |
| rs1805096 | 1:66102257 | G/A | 0.62 | 0.104 | 0.004 | 2.17E-183 | −0.121 | 2.99E-06 | 0.68 |
| rs4129267 | 1:154426264 | C/T | 0.61 | 0.088 | 0.004 | 1.20E-129 | −0.474 | 2.91E-06 | 0.10 |
| rs2794520 | 1:159678816 | C/T | 0.66 | 0.182 | 0.004 | 4.17E-523 | −0.049 | 3.17E-06 | 0.88 |
| rs10925027 | 1:247612562 | T/C | 0.40 | 0.036 | 0.004 | 4.25E-21 | −0.759 | 2.92E-06 | 0.01 |
| rs1260326 | 2:27730940 | T/C | 0.41 | 0.073 | 0.004 | 2.72E-92 | 0.278 | 2.95E-06 | 0.35 |
| rs13409371 | 2:113838145 | A/G | 0.39 | 0.048 | 0.004 | 5.07E-36 | −0.209 | 2.91E-06 | 0.47 |
| rs13233571 | 7:72971231 | C/T | 0.88 | 0.057 | 0.005 | 2.95E-25 | −0.180 | 4.22E-06 | 0.67 |
| rs4841132 | 8:9183596 | G/A | 0.92 | 0.065 | 0.006 | 2.00E-25 | 0.442 | 5.40E-06 | 0.41 |
| rs10778215 | 12:103537266 | T/A | 0.52 | 0.033 | 0.004 | 1.86E-20 | −0.222 | 2.87E-06 | 0.44 |
| rs7310409 | 12:121424861 | G/A | 0.60 | 0.137 | 0.004 | 2.54E-299 | 0.105 | 2.88E-06 | 0.71 |
| rs340005 | 15:60878030 | A/G | 0.63 | 0.030 | 0.004 | 1.01E-15 | 0.352 | 2.92E-06 | 0.23 |
| rs10521222 | 16:51158710 | C/T | 0.95 | 0.104 | 0.011 | 2.06E-22 | −1.450 | 6.99E-06 | 0.04 |
| rs2852151 | 18:12841176 | A/G | 0.40 | 0.025 | 0.004 | 1.36E-11 | −0.002 | 2.94E-06 | 0.99 |
| rs4420638 | 19:45422946 | A/G | 0.83 | 0.229 | 0.006 | 1.23E-305 | −0.425 | 4.16E-06 | 0.31 |
| rs1800961 | 20:43042364 | C/T | 0.97 | 0.112 | 0.011 | 4.63E-23 | −0.742 | 8.51E-06 | 0.38 |
| rs469772 | 1:91530305 | C/T | 0.81 | 0.031 | 0.005 | 5.54E-12 | 0.242 | 3.60E-06 | 0.50 |
| rs12995480 | 2:629881 | C/T | 0.83 | 0.031 | 0.005 | 1.24E-10 | 0.329 | 3.92E-06 | 0.40 |
| rs4246598 | 2:88438050 | A/C | 0.46 | 0.022 | 0.004 | 5.11E-10 | −0.200 | 2.89E-06 | 0.49 |
| rs9284725 | 2:102744854 | C/A | 0.24 | 0.027 | 0.004 | 7.34E-11 | −0.434 | 3.36E-06 | 0.20 |
| rs1441169 | 2:214033530 | A/G | 0.47 | 0.025 | 0.004 | 2.27E-11 | −0.130 | 2.81E-06 | 0.64 |
| rs2352975 | 3:49891885 | C/T | 0.31 | 0.025 | 0.004 | 6.43E-10 | 0.161 | 3.27E-06 | 0.62 |
| rs17658229 | 5:172191052 | C/T | 0.04 | 0.056 | 0.010 | 5.50E-09 | −0.274 | 6.67E-06 | 0.68 |
| rs9271608 | 6:32591588 | G/A | 0.17 | 0.042 | 0.005 | 2.33E-17 | 0.094 | 4.15E-06 | 0.82 |
| rs12202641 | 6:116314634 | C/T | 0.60 | 0.023 | 0.004 | 3.00E-10 | 0.187 | 2.94E-06 | 0.53 |
| rs1490384 | 6:126851160 | C/T | 0.49 | 0.025 | 0.004 | 2.65E-12 | 0.175 | 2.83E-06 | 0.54 |
| rs9385532 | 6:130371227 | C/T | 0.66 | 0.026 | 0.004 | 1.90E-11 | −0.403 | 3.25E-06 | 0.21 |
| rs1880241 | 7:22759469 | A/G | 0.51 | 0.028 | 0.004 | 8.41E-14 | −0.313 | 2.90E-06 | 0.28 |
| rs2710804 | 7:36084529 | C/T | 0.37 | 0.021 | 0.004 | 1.30E-08 | 0.298 | 2.91E-06 | 0.31 |
| rs2064009 | 8:117007850 | T/C | 0.58 | 0.027 | 0.004 | 2.28E-14 | −0.697 | 3.03E-06 | 0.02 |
| rs2891677 | 8:126344208 | T/C | 0.54 | 0.020 | 0.004 | 1.59E-08 | 0.212 | 3.00E-06 | 0.48 |
| rs643434 | 9:136142355 | A/G | 0.37 | 0.023 | 0.004 | 1.02E-09 | −0.041 | 3.05E-06 | 0.89 |
| rs1051338 | 10:91007360 | G/T | 0.30 | 0.024 | 0.004 | 2.27E-09 | 0.514 | 3.14E-06 | 0.10 |
| rs10832027 | 11:13357183 | A/G | 0.67 | 0.026 | 0.004 | 4.43E-12 | −0.394 | 2.96E-06 | 0.18 |
| rs10838687 | 11:47312892 | T/G | 0.79 | 0.031 | 0.004 | 9.12E-13 | 0.016 | 3.39E-06 | 0.96 |
| rs1582763 | 11:60021948 | G/A | 0.63 | 0.022 | 0.004 | 2.37E-09 | −0.083 | 2.97E-06 | 0.78 |
| rs7121935 | 11:72496148 | G/A | 0.62 | 0.022 | 0.004 | 5.28E-09 | 0.090 | 3.04E-06 | 0.77 |
| rs11108056 | 12:95855385 | C/G | 0.58 | 0.028 | 0.004 | 5.42E-14 | 0.318 | 3.02E-06 | 0.29 |
| rs2239222 | 14:73011885 | G/A | 0.37 | 0.035 | 0.004 | 9.87E-20 | 0.415 | 3.15E-06 | 0.19 |
| rs4774590 | 15:51745277 | G/A | 0.62 | 0.022 | 0.004 | 2.71E-08 | 0.110 | 3.07E-06 | 0.72 |
| rs1558902 | 16:53803574 | A/T | 0.40 | 0.034 | 0.004 | 5.20E-20 | 0.030 | 2.84E-06 | 0.92 |
| rs178810 | 17:16097430 | T/C | 0.56 | 0.020 | 0.004 | 2.95E-08 | −0.060 | 2.83E-06 | 0.83 |
| rs10512597 | 17:72699833 | C/T | 0.80 | 0.037 | 0.005 | 4.44E-14 | −0.048 | 3.87E-06 | 0.90 |
| rs4092465 | 18:55080437 | G/A | 0.62 | 0.027 | 0.004 | 3.11E-10 | −0.154 | 3.11E-06 | 0.62 |
| rs12960928 | 18:57897803 | C/T | 0.26 | 0.024 | 0.004 | 1.91E-09 | −0.296 | 3.34E-06 | 0.38 |
| rs2315008 | 20:62343956 | G/T | 0.68 | 0.023 | 0.004 | 5.36E-10 | 0.118 | 3.11E-06 | 0.70 |
| rs2836878 | 21:40465534 | G/A | 0.73 | 0.043 | 0.004 | 7.71E-26 | 0.289 | 3.10E-06 | 0.35 |
| rs6001193 | 22:39074737 | A/G | 0.63 | 0.028 | 0.004 | 6.53E-14 | −0.678 | 3.10E-06 | 0.03 |
| rs75460349 | 1:27180088 | A/C | 0.98 | 0.086 | 0.014 | 4.50E-10 | 0.477 | 9.43E-06 | 0.61 |
| rs1514895 | 3:170705693 | G/A | 0.30 | 0.027 | 0.004 | 2.70E-09 | 0.002 | 3.26E-06 | 0.99 |
| rs112635299 | 14:94838142 | G/T | 0.98 | 0.107 | 0.017 | 2.10E-10 | −2.150 | 1.22E-05 | 0.08 |
| rs1189402 | 15:53728154 | A/G | 0.63 | 0.025 | 0.004 | 3.90E-09 | 0.474 | 3.20E-06 | 0.14 |
*
Chromosome: position, hg19
**
beta, SNP-sepcific coefficients for association with circulating concentrations of CRP obtained from Ligthart et al, per unit increase in natural log transformed CRP (mg/L)
***
hazards difference for CRC-specific survival per unit increase in the count allele based on additive hazards model
Abbreviations: ISACC: the International Survival Analysis in Colorectal Cancer Consortium; HD: hazards difference; se: standard error