Table 2.

Association between genetically determined CRP concentrations and CRC-specific survival

		Additive hazards model			Cox proportional hazards model
		HD (95% CI) per 100,000 person-year		P	HR (95% CI)		P
Using individual-level data
52-SNP GRS
	Continuous*	−1.15	(−2.76, 0.47)	0.16	0.90	(0.79, 1.02)	0.10
	By quartiles
	Q1 (2.05,3.06]	1.00	Ref		1.00	Ref
	Q2 (3.06,3.24]	0.31	(−0.87, 1.49)	0.61	1.02	(0.93, 1.12)	0.67
	Q3 (3.24,3.41]	−0.52	(−1.71, 0.68)	0.40	0.96	(0.88, 1.05)	0.41
	Q4 (3.41,4.08]	−0.73	(−1.87, 0.41)	0.21	0.93	(0.85, 1.02)	0.14
Using summary statistics
	IVW	−1.12	(−2.72, 0.48)	0.17	0.90	(0.79, 1.02)	0.10
	MR-Egger	−1.29	(−3.68, 1.11)	0.29	0.88	(0.72, 1.06)	0.18
	Weighted median	−0.77	(−3.02, 1.47)	0.50	0.93	(0.77, 1.11)	0.40

^*Per one-unit increment in GRS;

All models adjusted for age at diagnosis, sex, body mass index, genotyping platform, study and principal components.

Abbreviations: CI: confidence interval; GRS: genetic risk score; HD: hazard difference; HR: hazard ratio; IVW: inverse-variance weighted; MR: Mendelian randomization.