. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2021 May 10;30(7):1349–1358. doi: 10.1158/1055-9965.EPI-20-1848

Table 3.

Association between genetically determined CRP concentrations and CRC-specific survival, by subgroups

52-SNP GRS		Total	Events^*	Cox proportional hazards model
52-SNP GRS		Total	Events^*	HR (95% CI)^**		P
All		16,918	3,808	0.90	(0.79, 1.02)	0.10
By stage at diagnosis^ⱡ
	Local	3,341	142	0.50	(0.24, 1.02)	0.06
	Regional	6,420	1,177	0.92	(0.73, 1.17)	0.51
	Distant	1,845	1,387	0.97	(0.75, 1.24)	0.79
By tumor location^║
	Colon	12,000	2,791	0.87	(0.75, 1.00)	0.06
	Proximal	6,205	1,365	0.86	(0.69, 1.07)	0.18
	Distal	4,879	932	0.98	(0.75, 1.29)	0.91
	Rectum	4,729	974	1.02	(0.79, 1.33)	0.85

Death events due to CRC within up to 10-year follow-up

^**

HRs represent per one-unit increase in GRS, and were adjusted for age at diagnosis, sex, body mass index, genotyping platform, study, and principal components; Additive models do not converge in subgroup analysis.

^ⱡ

Stage at diagnosis was defined using SEER summary stage (local: AJCC stage I; regional: stage II-IIl; distant: stage IV)

^║

Proximal colon was defined as from the cecum through transverse colon; distal colon was from the splenic flexure to sigmoid colon; rectum included the rectosigmoid junction and rectum. Abbreviations: CI: confidence interval; GRS: genetic risk score; HR: hazard ratio; AJCC: American joint committee on cancer.