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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Mol Cancer Res. 2021 Mar 22;19(7):1156–1167. doi: 10.1158/1541-7786.MCR-20-0867

Figure 5. Resistance to selective PI3K inhibitor BKM120 after loss of AP-2α.

Figure 5.

A & B. Invasion assay with BKM120 treatment revealed a decrease in invasion within 24 hours compared to vehicle treated cells in the HCT116 parental cell line, but no alteration in invasion occurred with BKM120 treatment in three AP-2α KO clones. C. Western blots showing stable knockdown of TFAP2A using shRNA in colon cancer cell lines HCT116, LS180, LoVo and SW40. D. Knockdown of TFAP2A induced resistance to the selective PI3K inhibitor BKM120, which led to a decrease in invasion compared to vehicle in shNT-treated cells.