Table 10:
Adjusted odds ratios, 95% confidence intervals, and p-values for the associations of demographic and biologic variables with PEth sensitivity (PEth ≥8 ng/mL) among observations with unhealthy drinking reported and complete case data (sensitivity analyses). Statistically significant comparisons are bolded.
| Predictors | Model 1 | Model 2 | Model 3 |
|---|---|---|---|
| N Studies | 21 | 13 | 9 |
| N | 4073 | 3019 | 1773 |
| AUDIT-C score* | |||
| 6 vs 4 | 1.78 (1.40–2.27, p<0.001) | 1.62 (1.29–2.02, p<0.001) | 1.45 (1.21–1.73, p<0.001) |
| 10 vs 4 | 3.37 (2.05–5.53, p<0.001) | 2.62 (1.78–3.87, p<0.001) | 2.12 (1.57–2.85, p<0.001) |
| Sex: Female vs Male | 0.86 (0.61–1.22, p=0.396) | 1.08 (0.80–1.47, p=0.610) | 1.15 (0.76–1.76, p=0.511) |
| Race/ethnicity | |||
| African vs White | 2.41 (0.81–7.21, p=0.115) | 2.96 (1.05–8.36, p=0.040) | 3.59 (0.82–15.72, p=0.089) |
| African American vs White | 1.30 (0.96–1.76, p=0.090) | 1.48 (0.99–2.22, p=0.055) | 1.71 (1.08–2.68, p=0.021) |
| Other vs White | 1.16 (0.72–1.86, p=0.540) | 1.06 (0.79–1.44, p=0.687) | 1.21 (0.90–1.64, p=0.214) |
| Age* | |||
| 30 vs 20 | 1.44 (0.93–2.23, p=0.098) | 1.61 (0.95–2.73, p=0.076) | 1.24 (0.44–3.47, p=0.655) |
| 40 vs 20 | 1.81 (0.89–3.69, p=0.101) | 2.17 (0.92–5.13, p=0.077) | 1.23 (0.37–4.15, p=0.685) |
| 50 vs 20 | 1.98 (0.86–4.58, p=0.110) | 2.45 (0.90–6.66, p=0.078) | 1.14 (0.35–3.72, p=0.734) |
| 60 vs 20 | 1.88 (0.82–4.32, p=0.135) | 2.31 (0.89–6.02, p=0.085) | 1.24 (0.44–3.47, p=0.824) |
| Method of blood collection: Venous vs finger-prick | 0.92 (0.29–2.93, p=0.885) | ||
| BMI (per 5 kg/m2) | 0.74 (0.66–0.83, p<0.001) | 0.72 (0.65–0.80, p<0.001) | |
| Hemoglobin (per 5 g/dl) | 2.19 (1.69–2.84, p<0.001) | 2.63 (1.84–3.74, p<0.001) | |
| HIV+ (vs HIV-) | 0.78 (0.68–0.89, p<0.001) | 0.76 (0.61–0.94, p=0.010) | |
| FIB-4 score | |||
| 1.45–3.25 vs <1.45 | 1.27 (1.02–1.58, p=0.035) | ||
| >3.25 vs <1.45 | 1.81 (1.27–2.59, p=0.001) | ||
*
Fitted values from quadratic variable