Table 4.
Adjusted odds ratios 95% confidence intervals, and p-values for the associations of demographic and biologic variables with PEth sensitivity (PEth ≥8 ng/mL) among observations with unhealthy drinking reported. Statistically significant comparisons are bolded.
| Predictors | Model 1 | Model 2 | Model 3 |
|---|---|---|---|
| N Studies | 21 | 13 | 9 |
| N | 4073 | 3188 | 2367 |
| AUDIT-C score* | |||
| 6 vs 4 | 1.78 (1.40–2.27, p<0.001) | 1.64 (1.28–2.10, p<0.001) | 1.38 (1.11–1.72, p<0.001) |
| 10 vs 4 | 3.37 (2.05–5.53, p<0.001) | 2.62 (1.79–3.83, p<0.001) | 2.10 (1.55–2.87, p<0.001) |
| Sex: Female vs Male | 0.86 (0.61–1.22, p=0.396) | 1.08 (0.82–1.42, p=0.589) | 1.12 (0.81–1.54, p=0.500) |
| Race/Ethnicity | |||
| African vs White | 2.41 (0.81–7.21, p=0.115) | 3.05 (1.07–8.72, p=0.037) | 3.57 (0.73–17.42, p=0.116) |
| African American vs White | 1.30 (0.96–1.76, p=0.090) | 1.54 (1.00–2.37, p=0.047) | 1.70 (1.06–2.72, p=0.027) |
| Other vs White | 1.16 (0.72–1.86, p=0.540) | 1.10 (0.85–1.43, p=0.471) | 1.22 (0.90–1.64, p=0.202) |
| Age* | |||
| 30 vs 20 | 1.44 (0.93–2.23, p=0.098) | 1.68 (1.02–2.76, p=0.041) | 1.10 (0.62–1.95, p=0.737) |
| 40 vs 20 | 1.81 (0.89–3.69, p=0.101) | 2.27 (1.01–5.12, p=0.048) | 1.14 (0.45–2.94, p=0.786) |
| 50 vs 20 | 1.98 (0.86–4.58, p=0.110) | 2.47 (0.95–6.40, p=0.062) | 1.12 (0.36–3.42, p=0.847) |
| 60 vs 20 | 1.88 (0.82–4.32, p=0.135) | 2.17 (0.86–5.45, p=0.099) | 1.03 (0.34–3.11, p=0.965) |
| Method of blood collection: Venous vs finger-prick | 0.92 (0.29–2.93, p=0.885) | --- | --- |
| BMI (per 5 kg/m2) | 0.74 (0.66–0.83, p<0.001) | 0.73 (0.65–0.81, p<0.001) | |
| Hemoglobin (per 5 g/dl) | 2.12 (1.52–2.96, p<0.001) | 2.28 (1.57–3.30, p<0.001) | |
| HIV+ (vs HIV-) | 0.77 (0.66–0.89, p<0.001) | 0.78 (0.64–0.95, p=0.013) | |
| FIB-4 score | |||
| 1.45–3.25 vs <1.45 | 1.29 (1.02–1.63, p=0.032) | ||
| >3.25 vs <1.45 | 1.87 (1.28–2.75, p=0.001) |
*
Fitted values from quadratic variable