Table 7.

Adjusted odds ratios, 95% confidence intervals, and p-values for the associations of demographic and biologic variables with PEth sensitivity (PEth ≥8 ng/mL) among persons reporting unhealthy drinking, data limited to observations with prior 30-day alcohol use assessed/reported (sensitivity analyses). Statistically significant comparisons are bolded.

Predictors	Model 1	Model 2	Model 3
N Studies	14	10	7
N	2552	2173	1538
AUDIT-C score*
6 vs 4	1.50 (1.13–1.97, p<0.001)	1.41 (1.01–1.96, p=0.043)	1.13 (0.81–1.57, p=0.471)
10 vs 4	3.38 (2.26–5.05, p<0.001)	2.81 (1.96–4.01, p<0.001)	2.25 (1.39–3.65, p=0.001)
Sex: Female vs Male	0.82 (0.57–1.17, p=0.269)	1.05 (0.80–1.38, p=0.743)	1.14 (0.83–1.55, p=0.412)
Race/ethnicity
African vs White	2.70 (0.94–7.76, p=0.065)	3.21 (1.30–7.95, p=0.012)	3.57 (0.80–15.96, p=0.095)
African American vs White	1.53 (1.01–2.30, p=0.042)	1.70 (1.07–2.67, p=0.023)	1.96 (1.11–3.49, p=0.021)
Other vs White	0.76 (0.58–1.00, p=0.048)	0.78 (0.58–1.07, p=0.123)	0.79 (0.50–1.26, p=0.322)
Age*
30 vs 20	1.63 (0.90–2.95, p=0.109)	1.64 (0.83–3.24, p=0.154)	0.91 (0.47–1.77, p=0.790)
40 vs 20	2.20 (0.86–5.65, p=0.102)	2.07 (0.71–6.04, p=0.182)	0.81 (0.28–2.31, p=0.689)
50 vs 20	2.47 (0.84–7.23, p=0.100)	2.01 (0.62–6.56, p=0.246)	0.69 (0.21–2.23, p=0.532)
60 vs 20	2.30 (0.79–6.68, p=0.125)	1.50 (0.53–4.27, p=0.443)	0.56 (0.19–1.64, p=0.294)
Method of blood collection: Venous vs finger-prick	0.73 (0.19–2.72, p=0.634)
BMI (per 5 kg/m2)		0.73 (0.62–0.86, p<0.001)	0.73 (0.62–0.86, p<0.001)
Hemoglobin (per 5 g/dl)		2.13 (1.46–3.12, p<0.001)	2.32 (1.43–3.77, p<0.001)
HIV+ (vs HIV-)		0.78 (0.39–1.57, p=0.487)	0.98 (0.48–2.02, p=0.959)
FIB-4 score			1.00
1.45–3.25 vs <1.45			1.43 (0.97–2.11, p=0.074)
>3.25 vs <1.45			2.30 (1.49–3.54, p<0.001)

^*Fitted values from quadratic variable