Skip to main content
. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2021 May 5;30(7):1397–1407. doi: 10.1158/1055-9965.EPI-21-0055

Figure 3.

Figure 3.

Joint associations of tumor associated stromal cellular density (SCD) and tumor characteristics with clinical outcomes among luminal breast cancer patients. Hazards ratios (HR) and 95% confidence intervals for the joint associations between SCD and lymph nodal involvement (A), tumor size (B), histologic grade (C), luminal-like subtype (D), IHC4 score (E), and stromal tumor infiltration lymphocytes, sTILs (F) and clinical outcomes (10-year disease-free survival (DFS) and 10-year overall survival (OS)) among hormone receptor-positive breast cancer patients from three independent study populations including CHCAMS (China; DFS), PBCS (Poland; OS) and PLCO (United States; OS). Hazard ratios and corresponding estimates were obtained from multivariable Cox proportional hazard regression models accounting for standard clinical factors, including age, lymph nodal involvement, tumor size, histologic grade, subtype, and systemic therapy, as well as total tissue area. Each primary model exempted the variable in the joint SCD-clinical factor classification.