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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Semin Cell Dev Biol. 2021 Jan 4;116:62–70. doi: 10.1016/j.semcdb.2020.12.004

Figure 2. Human glial progenitor cells colonize and then dominate human glial-chimeric mouse brains.

Figure 2

A. 9-month old mouse engrafted neonatally with human GPCs, shows predominance of human GPCs over time. Human-specific NG2, green; mouse NG2, red. B. Higher power of A, showing dense engraftment of human GPCs. C. Cortical strips show progressive dominance of human GPCs (green) relative to mouse (red) at 3 (left), 9 (center) and 13 (right) months after neonatal engraftment.

Scales: A, 400 μm; B, 100 μm; C, 150 μm. Adapted from (Windrem et al., 2014).