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. 2021 Jan 4;26(6):1775–1789. doi: 10.1038/s41380-020-00991-1

Fig. 1. Multiple postsynaptic psychiatric risk factors include a Homer1-binding motif.

Fig. 1

a Diagram of PPXXF motif-containing proteins in PSD. b Functional analysis of conserved (in human, bovine, mouse, and rat) PPXXF motif-containing proteins in PSD. c Enrichment of BD, ASD, and SZ risk factors (identified through GWAS, SFARI gene archive and de novo studies, respectively) among PPXXF motif-containing proteins in the combined human and mouse PSD. ***p < 0.001; hypergeometry test. d Diagram of PPXXF motif-containing proteins in the PSD is encoded by psychiatric risk genes. e Protein interaction network generated from the list of PPXXF motif-containing PSD proteins is encoded by psychiatric risk genes in d. The representative majority of a subnetwork is visualized and annotated by Cytoscape. The size of node indicates betweenness centrality. Known interactors with Homer1/2/3 from BioGrid and text mining were colored emerald. Edges indicate known and predicted protein-protein interactions, including experimental data from the STRING database. f Schematic representation of the Homer1 recognition motifs in ankyrin-G (190, 270, and 480 kDa) isoforms. g Amino acid sequence alignment of human, bovine, mouse, and rat ankyrin-G regions containing the Homer-binding motif PPXXF. Sequence alignments were performed by Clustal Omega. SFARI: Simons Foundation Autism Research Initiative.