Fig. 4.

Increased expression of inflammatory cytokines in the parietal cortex of Aβ+ individuals. a–s Cytokine expression assessed by multispot immunoassays revealed increased levels (dotted line) of a IL-1β, two-tailed Student t test; t (22) = 2.46, p =0.022; Aβ−, n = 12; Aβ+, n = 12; c MCP-1, two-tailed Mann–Whitney test; U = 29, p = 0.042; Aβ−, n = 12; Aβ+, n = 10, in the parietal cortex of non-demented individuals with Aβ deposition as compared with individuals without Aβ deposition in this brain region. b, d–s Expression cytokine levels that did not differ between Aβ− and Aβ+ individuals (IL-6, eotaxin-3, IL-1α, IL-4, IL-7, IL-8, IL-10, IL-12p40, IL-13, IL-15, IL-16, IFNγ, IP-10, MDC, MIP-1β, TARC, and TNFα). Data are displayed in boxplots where the median is represented by the horizontal line and the whiskers represent the 25th and 75th percentiles. ^*p <0.05