Table 2.
Biochemical parameters of male rats receiving melittin post isoniazid and rifampicin-induced hepatotoxicity
| NC | T | Mel15 | Mel30 | NR | |
|---|---|---|---|---|---|
| DB (μmol/l) | 1.0 ± 0.451 | 7.05 ± 1.84a**** | 1.0 ± 0.38b**** | 1.0 ± 0.27 b**** | 1.0 ± 0.31b**** |
| TB (μmol/l) | 1.6 ± 0.94 | 10.45 ± 2.13a**** | 2 ± 1.05b**** | 2.82 ± 1.49 b**** | 2.87 ± 0.89 b**** |
| ALT (U/L) | 26.83 ± 11.44 | 73.5 ± 16.99a*** | 38.5 ± 14.27b** | 44.33 ± 15.93b* | 50.33 ± 17.44 |
| AST (U/L) | 92.17 ± 31.64 | 288.3 ± 147.7a** | 137.7 ± 15.81b* | 147 ± 32.83b* | 183.2 ± 79.05 |
| ALP (U/L) | 187.2 ± 25.86 | 286.5 ± 53.07a*** | 164.2 ± 19.59b**** | 166.5 ± 18.41b**** | 189 ± 27.41b*** |
| LDH (U/L) | 762 ± 63.68 | 3046 ± 768.1a**** | 1577 ± 338.4b*** | 1640 ± 693.3b*** | 2155 ± 261.2b* |
| TSP (g/L) | 66 ± 8.37 | 75.5 ± 0.84a** | 76 ± 1.67 | 70 ± 2.76 | 63.5 ± 2.51b*** |
Results are expressed as mean ± SD (n = 6)
NC control, T Toxic, Mel15 Melittin15μg, Mel30 Melittin30μg, NR Normal recovery
*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001
a: significant Vs NC group, b: significant Vs T group