Table 2.
Clinicopathological characteristics of patients in MGRS group
| Amyloidosis (n = 25) | Cryo-GN (n = 7) | MIDD (n = 3) | PGNMID (n = 5) | P value | |
|---|---|---|---|---|---|
| Male [n (%)] | 17 (68.0) | 4 (57.1) | 2 (66.7) | 2 (38.1) | 0.336 |
| Age (year) | 58.0 ± 7.7 | 53.3 ± 16.4 | 69.7 ± 8.4 | 56.4 ± 7.5 | 0.209 |
| Renal disease duration before renal biopsy (months) | 10.0 ± 10.8 | 7.8 ± 7.0 | 22.0 ± 22.7 | 13.7 ± 10.3 | 0.289 |
| Hematuria [n (%)] | 2 (23)a,c | 6 (85.7) | 1 (33.3) | 3 (60.0) | 0.001 |
| Proteinuria (g/24 h) | 3.8 ± 2.3 | 7.0 ± 2.9a,d,e | 2.0 ± 1.6 | 2.1 ± 1.5 | 0.002 |
| Albumin (g/L) | 25.8 ± 5.8 | 25.4 ± 3.9 | 36.6 ± 1.7b,d | 31.1 ± 9.7 | 0.017 |
| Hemoglobin (g/L) | 123.4 ± 16.5a,b,c | 91.1 ± 12.5 | 93.0 ± 28.2 | 104.6 ± 16.5 | 0.000 |
| SCr (μmol/L) | 134.2 ± 216.8 | 243.3 ± 197.3 | 386.3 ± 221.0b,f | 78.6 ± 33.1e | 0.002 |
| eGFR (mL/min/1.73m2) | 81.7 ± 37.6 | 29.0 ± 17.1a,e | 18.4 ± 10.7 b,f | 80.1 ± 30.4 | 0.001 |
| Low serum C3 [n (%)] | 4 (16.0)c | 3 (42.9) | 2 (66.7) | 5 (100) | 0.089 |
| Abnormal serum κ/λ ratio [n (%)] | 13 (52.0) | 3 (42.9) | 2 (66.7) | 0 (0) | 0.269 |
| Abnormal urine κ/λ ratio [n (%)] | 14 (60.9) | 1 (14.3) | 2 (66.7) | 0 (0) | 0.131 |
| Abnormal sIFE [n (%)] | 16 (66.7) | 5 (71.4) | 2 (66.7) | 1 (20) | 0.237 |
| Abnormal uIFE [n (%)] | 17 (77.3) | 3 (75) | 2 (100) | 1 (50) | 0.702 |
| κ (sIFE, [n (%)]) | 3 (20.0)a | 4 (80) | 1 (50) | 0 (0) | 0.031 |
| κ (uIFE, [n (%)]) | 3 (18.8) | 1 (33.3) | 1 (50.0) | 0 (0) | 0.687 |
| Renal monotypic κ [n (%)] | 4 (16.0)c | 5 (71.4) | 2 (66.7) | 4 (80) | 0.003 |
| Global glomerulosclerosis (%) | 14.4 ± 16.4 | 17.4 ± 22.8 | 42.3 ± 13.7b,d,f | 12.6 ± 13.8 | 0.081 |
| Segmental glomerulosclerosis (%) | 0 | 3.1 ± 8.3 | 0 | 2 ± 4.5 | 0.236 |
| Crescents (%) | 0 | 18.0 ± 32.2a | 0 | 8.2 ± 6.8 | 0.319 |
| IFTA | 1.04 ± 0.69a | 1.86 ± 0.69e | 3.0 ± 0.0b,d,f | 1.0 ± 0.0 | 0.000 |
| Interstitial inflammation | 0.79 ± 0.66a,b | 2.14 ± 0.69 | 2.33 ± 0.58 | 1.40 ± 0.89 | 0.000 |
| Podocyte effacement (%) | 2.6 ± 0.6 | 2.6 ± 0.8 | 2.3 ± 0.6 | 2.4 ± 0.9 | 0.883 |
MGRS monoclonal gammopathy of renal significance; MM multiple myeloma; MGUS monoclonal gammopathy of undetermined significance; MIg monoclonal immunoglobulin; monoIg monotypic immunoglobulin; SCr serum creatinine; eGFR the estimated glomerular filtration rate; sIFE serum immunofixation electrophoresis; uIFE urine immunofixation electrophoresis; IFTA interstitial fibrosis/tubular atrophy
aP < 0.05, Amyloid vs Cryo group
bP < 0.05, Amyloid vs MIDD group
cP < 0.05, Amyloid vs PGNMID group
dP < 0.05, Cryo vs MIDD group
eP < 0.05, Cryo vs PGNMID group
fP < 0.05, MIDD vs PGNMID group