FIGURE 3.

Dual target inhibition of CB₁R and iNOS prevented decline with PF in HpsPF mice. (A) Hydroxyproline content as fibrosis measurement. (B) Pressure‐volume curve, (C) forced expiratory volume, (D) tissue elasticity, and (E) tissue damping as measures of lung function. Data represent mean ± SEM. n = 13 mice for control (Ctrl, pale ear mice infused with saline instead of bleomycin), n = 18 HpsPF mice for vehicle (Veh), and n = 18 HpsPF mice for MRI‐1867 (MRI‐1867)‐treated groups. Data were analyzed by one‐way ANOVA followed by Dunnett's multiple comparisons test. * (p < 0.05) indicates significant difference from the control group. # (p < 0.05) indicates significant difference from the HpsPF mice treated with vehicle (Veh) at 42 day