FIGURE 5.

Only MRI‐1867, but not rimonabant or 1400W, reduced fibrosis and improved PFT in pulmonary fibrosis in HpsPF mice. (A) Hydroxyproline content as fibrosis measurement. (B) Pressure‐volume curve, (C) forced expiratory volume, (D) tissue elasticity, and (E) tissue damping as measures of lung function. Data represent mean ± SEM. n = 9 mice per group. Control group (Ctrl) were pale ear mice infused with saline instead of bleomycin. HpsPF mice (pale ear mice challenged with bleomycin) were either given vehicle (veh), MRI‐1867, rimonabant (Rim), or iNOS inhibitor (1400W). Data were analyzed by one‐way ANOVA followed by Dunnett's multiple comparisons test. * (p < 0.05) indicates significant difference from the control group. # (p < 0.05) indicates significant difference from HpsPF mice treated with vehicle (Veh) at 42 day