Table 3. Analysis of bleeding characteristics and wilate treatment.
| Population a | Patients experiencing bleed, n (%) |
Number of bleeds | Type | Severity | Treatment with wilate | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Spontaneous, n (%) |
Trauma, n (%) |
Other/ unknown, n (%) |
Mild, n (%) |
Moderate, n (%) |
Severe, n (%) |
Unknown, n (%) |
1–2 infusions, % ( n ) |
>2 infusions, % ( n ) |
Infusions/treatment, median (range) |
Dose [IU/kg], median (range) |
|||
| Prophylaxis ( N = 25) | 18 (72.0) | 233 | 154 (66.1) | 42 (18.0) | 37 (15.9) | 87 (37.3) | 103 (44.2) | 20 (8.6) | 23 (9.9) | 85.1 (149/175) | 14.9 (26/175) | 1 (1–14) | 55.4 (8.3–1441.3) |
| On-demand ( N = 29) | 25 (86.2) | 150 | 102 (68.0) | 31 (20.7) | 17 (11.3) | 27 (18.0) | 107 (71.3) | 15 (10.0) | 0 (0) | 94.2 (130/138) | 5.8 (8/138) | 1 (1–13) | 33 (8.3–625) |
| Menstrual bleeding ( N = 9) | 9 (100) | 56 | – | – | – | 5 (8.9) | 20 (35.7) | 26 (46.4) | 5 (8.9) | 46.4 (26/56) | 53.6 (30/56) | 3 (1–7) | 79.1 (10–339.8) |
a
Two patients changed from on-demand treatment to prophylaxis, and three patients changed from prophylaxis to on-demand treatment. For all analyses by treatment regimen, these five patients were included in both analysis populations. Seven patients treated on-demand and two treated prophylactically also received treatment for menstrual bleeding.