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Study overview: schematic presenting the hypothesis and four major domains studied—(i) shared genomic regions between LTL and brain volume measures and gene-based associations for LTL in brain tissue-based (ii) transcriptomics—combined brain tissue (meta-analyzed from different regions of the brains) and prefrontal cortex, (iii) methylomics—combined brain tissues (meta-analyzed) and (iv) Hi-C chromatin profiles—adult and fetal brain, astrocytes and neurons.
